What is a Nucleofill treatment?
The product contains high molecular weight polynucleotide chains whose biochemical peculiarities make it highly viscoelastic and capable of binding and orient in space a considerable amount of water molecules, which are primarily retained in the hydrophilic groups level of phosphorylated sugars of the individual nucleotides.
​
​
Nucleofill consists of pure Polynucleotide gel, which stimulates i.a. fibroblasts, osteoblasts and myofibroblasts by binding to receptors on the cell membrane. This causes signaling molecules inside the cells to signal increased activity Nucleofill activates, among other things, receptors CD39 and CD40 on the fibroblasts that are responsible for stimulation of Collagen type 1.
When Polynucleotides stimulate the myofibrils inside the cytoplasm, this provides an immediate lift and the ability to contour the face using Cannula technique.
The polynucleotide stimulate various cell receptors, which attracts stem cells to the area. Stem cells change to the type of cells needed in the area, e.g. fibroblasts. In this way, a repair of the tissue is started, and this can last for several months after a treatment session of e.g. 2-3 consecutive treatments, finished.
The nucleofill gel lies in the tissue for approx. 15 days, and the degradation products will also have a positive effect on the tissue. After the product is removed from the tissue, a cascade of processes has already been initiated for is important for bio-revitalization and renewal and repair of skin and other types of tissues.
What do you achieve with Nucleofill: Bio-revitalization, Skin tightening, Contouring of cheeks and jaw line, reduces deep lines and wrinkles, reduce and block free radicals, reduce scars and stretch marks.
Moisturizing effect
The strong moisturizing ability is mainly due to the water retention capabilities of the hydrophilic groups of the phosphorylated sugars of the single nucleotides.
An “electrostatic sponge” is able to guarantee cellular well-being by conferring deep hydration to tissues.
Free radical scavenger effect
The polymeric macromolecules are able to also play an immediate “scavenger” action against free radicals.
This effect of this polynucleotide gel is possible thanks to the chemical structure capable of blocking free radicals in the nitrogenous ring.
Moreover, the progressive degradation of polynucleotide molecules by enzymes present in the extracellular environment, free metabolites which, in turn, accentuate the protection activity against free radicals.
Biostimulating effect
The bio-stimulating effect is given both by the presence of nucleoside structures capable of activating cell membrane receptors and by metabolites that are produced by the enzymatic attack during the degradation process. A slow and continuous effect.
By promoting the metabolic activity of the fibroblastic cells, polynucleotides collaborate to reintegrate into the dermis various fundamental autologous components (glucoseaminoglycans, proteins, glycoproteins, fibrils, etc.) tending to maintain their physiological functionality.
Their repeated administration over time determines:
-
protracted isosmotic hydration of the dermal matrix
-
an anti-radical action
Both of these effects combine to recreate in the dermal matrix the most favorable physiological conditions for the regeneration and metabolic activity of fibroblasts, with long-lasting biorevitalizing effects.
The maturation of fibroblasts in myofibroblasts and the production of collagen determines a strong specific lifting and revitalizing effect suitable for all skin types.
​Indications:
​
-
Skin laxity with poor circulation
​
-
Dehydrated skin
​
-
Skin submitted to oxidative stress
​
-
Stretch marks
​
-
Scars
​
-
For those who want firming and contouring, more definition.
​
-
Bio-stimulation and increase in collagen type 1.
It’s recommended to have 2 treatments with 2-4 weeks in between each session, in severe cases you can have up to 4 treatments with 2-4 weeks intervals.